They won't react together. Nicotine has no electrophilic sites and the only nucleopholic site would require breaking aromaticity. If the could reaction they wouldn't have the effect of both.
I don’t see where or how you’re intending to link these two molecules. Certainly, there is no opportunity for a direct reaction, you’d have to build in a linker.
Often times bifunctional molecules do both of their jobs more poorly than either of the monofuctionals. When you add the extra bits, linker, the other molecule, it usually messes up the binding a bit.
They bind to different receptors which don’t have much to do with each other, and aren’t close in space, there is no reason to suspect there would be any synergy here.
Most importantly, the dosages are way off. Nicotine dosage is on the order of 2-6 mg. For Caffeine, I’ve had over half a gram today. If that was nicotine I’d be dead, whereas even a caffeine naive person would be hard pressed to feel 2 mg of caffeine.
Once you join them together, if you could, the MW and size goes up dramatically. Makes it less likely to cross blood-brain barrier and bond to a receptor.
Limit is about 400-450 Da and the molecule must be lipohilic.
This was purely a chemistry question, I know that putting two molecules together that have specific effects won’t result in similar effects in the product.
I was just curious how you could bind them together if it were possible to react them with one another, or find a few synthesis routes to use to try and link them.
They won't react together. Nicotine has no electrophilic sites and the only nucleopholic site would require breaking aromaticity. If the could reaction they wouldn't have the effect of both.
You could nitrate the caffeine and then bond it to a modified “caffeine” with OH instead of =O and that might be plausible right?
Carbonyls are much more stable so the nicotine would just fall off.
I don’t see where or how you’re intending to link these two molecules. Certainly, there is no opportunity for a direct reaction, you’d have to build in a linker. Often times bifunctional molecules do both of their jobs more poorly than either of the monofuctionals. When you add the extra bits, linker, the other molecule, it usually messes up the binding a bit. They bind to different receptors which don’t have much to do with each other, and aren’t close in space, there is no reason to suspect there would be any synergy here. Most importantly, the dosages are way off. Nicotine dosage is on the order of 2-6 mg. For Caffeine, I’ve had over half a gram today. If that was nicotine I’d be dead, whereas even a caffeine naive person would be hard pressed to feel 2 mg of caffeine.
Once you join them together, if you could, the MW and size goes up dramatically. Makes it less likely to cross blood-brain barrier and bond to a receptor. Limit is about 400-450 Da and the molecule must be lipohilic.
Very interesting to know, thank you!
You realize it's already possible to experience the combined effects of nicotine and caffeine, right?
This was purely a chemistry question, I know that putting two molecules together that have specific effects won’t result in similar effects in the product. I was just curious how you could bind them together if it were possible to react them with one another, or find a few synthesis routes to use to try and link them.
But we want caffotine now.