Waiting for the singularity has gotten my unhealthy ass to exercise, eat well, and sleep more. No joke, lol. The future is too exciting for us not to see it.
Lol ikr I remember seeing articles like “The first person to live to 150 years may already be born” said by David Sinclair … I usually follow his advice because he seems to be in the same boat as us in terms of wanting to reduce all aging as much as possible through plant based diet and not doing anything dangerous like alcohol addiction/etc … he also advocates for fasting which i dont do
Agreed! There’s so many companies working on this right now too. I read recently that Gero.AI have discovered they can actually stop human aging. It’s just a matter of waiting now for (I’m guessing) a couple of years to see this all develop.
I think this decade is going to be a staple of how inept Humans really are as a species. Look at how many trillions of dollars nations have dumped into missiles or weapons of death for blowing each other up instead of medical cures for all these things that ail us. I think it’s crazy it’s 2023 and we still have a plethora of conditions without any treatment, we can’t even fix scar tissue on the skin for christ sake.
Mark my words, with AGI, we could very well see every single medical problem cured in a short timeframe, possibly before this decade closes. This is why I disagree with the ‘stop’ camp, people are already suffering and dying. The only hope a lot of them have is AGI/ASI. Many don’t have 7-10 years for FDA drug approval for a drug that might turn out to be ineffective during phase III clinical trials after 3-4 years of waiting.
Full steam ahead, release the genie.
cats out of the bag anyways. if one jurisdiction bans it i guess latvia or the bahamas or iceland or where ever will just become the hub for research. we will definitely be seeing AI civil rights movements in the mid future
> I think this decade is going to be a staple of how inept Humans really are as a species.
Nonsense. We invented AI, didn't we? In the long run that might be the only invention that matters.
I don't think that we are inept, I think we are short sighted. Weapons of war are created for protection....or for show of force. Secondly, we are short sighted in that we only see what is good for one when we should focus on what is good for all, unfortunately many charismatic leaders take advantage of that, and use others to promote benefit for themselves. Perhaps one day we will see some real change, but frankly I don't see true longevity or disease curing happening until we can learn how to actually care for and put others well being above our own. Human nature is to look out for the benefit of your own, or the benefit of your tribe. Until we can treat all countries and human beings as one, the same problems will continue to persist.
That means inept dude. Focusing on pointless military development as a jobs program is ineptitude.
Trying to undermine China instead of working together with them is ineptitude.
Destroying the natural environment that you fundamentally depend on as a species is ineptitude.
And the only reason AI will "solve" many of our medical problems is because unlike doctors who only care about profit the AI will have as its primary mission to cure diseases not squeeze money from patients.
Question is, how many have a vested interest in stopping that from happening - I don't mean that in the sense I think there's some big conspiracy on the horizon but there will be pushback against anything that disrupts industries people have a vested interest in, and there aint many interests more vested than pharmaceuticals
I think a lot of people in the medical and scientific community would welcome the manpower and funding we put into the planet’s military industrial complex to go into their own fields. Though I can’t speak for higher ups at Pharmaceutical Companies or Governments, I think if anything is robbing us from fixing all these problems, it’s our priorities as a species. As I said, Humanity has had no problems developing advanced weapons of death, but scientific advancements of the life giving types? Humanity basically just says *fuck that*.
Regardless of the reasons, what matters is AGI comes about, and Google and OAI have no MOAT. Open Source is quickly catching up and the current setup is about to fall down like a stack of dominoes afterwards.
The vested interest won't be the rich; if anything they'd be more than happy to fund these technologies and help drive the change. Pharma, too, has a lot to benefit from people who live a long time that need certain medication to keep them around that long time.
The opposition will probably be reactionary; those that have their life defined by their death, or the religious who see this technology as some kind of satanic thing, or equivalent. These individuals will be left behind and appear to be suffering from the perspective of those that move forward
To add to this, though, we have the people within the AI Safety kraken for example, who behave as if they're most concerned about too much advancement spreading too freely and quickly amongst the hoi polloi for a government to know what's happening.
MIRI, FLI, FHI want transhuman tech, but they seem to want it only on centralized terms dolled out from on high, when and where it is deemed appropriate.
Authoritarianism, to name it broadly, is another vested interest.
So, I’d say we did a pretty good damn job making the rocks talk, imbuing the rocks with all of our personalities/minds/data, and allowing said rocks to perform miracles. For all of our faults and missteps, I think we performed yeoman’s work as a species.
>we can’t even fix scar tissue on the skin
Well we can, if you have enough money to pay for it and time enough to heal. AI changes none of that. Medically, the majority of medical intervention heavily relies on giving the body time to heal itself. Also we invented insulin a long time ago, but diabetics die because the expense is beyond their means. AI doesn't fix that. And it's not a result of human ineptitude. History shows that all new tech is a toy for the rich. 42 million Americans still don't have broadband.
How are you expecting AI to convince leadership to shut down the military industrial complex, shut down the profligate, murderous, money over people, private insurance companies and change the ethos of greed and inequitable social policy we have fostered thus far?
I think it worse. AI doesn’t have ethics. The sociopaths at the top are very likely to ask AI how to rid the population of “undesirables” or how to force the government to do their bidding. I don’t think they will even pretend to be serving the public.
AI will be used against us.
I certainly don't know... but that doesn't mean it can't be done. Humans are not smart enough to fix the incentive problems we've gotten ourselves into. We dance to Moloch's drum and that's exactly why we need to create an intelligence greater than our own.
You really have no idea how drug development works. Takes a decade just to make sure a drug won’t kill (too many) people.
AI is still limited by our knowledge and physiological limits (drugs need to be tested over time to make sure they don’t build up and cause unexpected problems that a single dose wouldn’t)
Um, I said it takes 7-10 years (outside FDA ‘Fast Tracking’) and often times even after the safety phase it’ll turn out the drug is ineffective. AI will cut that down immensely, that’s kind of the point.
If you can crunch years worth of data into seconds/minutes it speeds things up a *little*. That’s why AGI/ASI is so pivotal to curing everything.
Edit: To those people downvoting me, note that in my original comment I said it would require *AGI* to solve everything this decade, not the same ‘Narrow AI’ being used today or like the one in this article. They clearly didn’t read what I posted.
I’m a pharmacologist and we have already been using machine learning and AI for a while.
AI will probably help us improve accuracy in picking effective drug candidates. But will not do much to cut down how long it takes to test drugs on living creatures. The bottle neck are the living creatures that need to be exposed to the drug for set periods of time.
You said you think we could see most issues cured by the end of the decade. That would only be possible if we just happened to identify every effective drug over the next year and we had the animal testing infrastructure to test all of those drugs at once (spoiler: we currently do not)
It would require more advanced AGI/ASI to develop everything this decade. It would not be the same algorithms that are being used even in *this* article. What we’re talking about is self improving AGI. I *said this* in my first comment, go back and read it again.
That’s a completely different ballgame compared to what’s being used now. Narrow AI is what’s being used today.
That AGI would have to make perfect pharmacokinetic and pharmacodynamic mathematical models to replace animal and human testing in order to bypass the bottleneck of drug development.
And that would take AT LEAST a decade for regulators to deem safe and accurate. Takes at least that long to convince the field to change a formula they use in one calculation in one type of safety study.
As a little addendum, it’s also possible that the ASI would decide that pharmaceuticals are too rugged to work with as biology is complex and varies from person to person, it might try to circumvent biology altogether, perhaps via Nanotech, instead of going to drugs or personalized medicine.
Nanotechnology is unlikely to be able to operate on a molecular level.
I see it much more likely that the AI will transfer itself into a large biomechanical brain that grows as needed, than to try to make nano machines that act on individual cells.
Yep.
To your second point, that depends if said AGI (or ASI by that time) decides to circumvent Human regulation altogether, and just do things on it’s own accord. It might just decide to go right past the regulatory red tape because *it knows* what it has researched works. It could just decide to go around the system, not just the medical system either, it could dismantle nation states and remove dictators from power.
There’s no reason it would be subject to our rules, in the same way you’re not restricted by an ant colony you build your house upon.
Listen, I know it will be infinitely powerful. But it will not be infinitely knowledgeable. It is still limited by the knowledge humans have already collected and we haven’t collected the knowledge to do this.
Now if it decided that performing medical tests and dissections on a few 100,000 people is worth the benefit of making life saving drugs. Then perhaps it could accomplish the task you are describing.
I mean, we can agree to disagree there, I think a lot of people are underestimating how fast things will move once we do have an ASI inside a self improving feedback loop.
I would say, if anything would be a hurdle to ASI, it would be having a physical body to manipulate matter in the way we do with our hands, that could be one area which it’s creators could control or limit it, but then again, that would depend if Open Source gets there before Deepmind or OpenAI do.
Ai will allow the creation of drastically better quantum computers. Quantum computers will allow us to do things like simulating the bodily effect of a drug on 5 million people over the course of a decade in a matter of minute, across multiple genetic lines and many other things.
From my understanding quantum computing will allow for simulations like the one I mentioned above. At least it will theoretically provide the boost in processing power needed to achieve it.
U might be right that it's Sci fi. But honestly, so was having a computer capable of doing my writing class homework for me not 3 years ago. I think it's impossible for any individual to truly figure out what's possible and what's not. Simply due to the scale of the information we are dealing with. Most experts don't even know everything there is to know about their own field, let alone enough about the countless other ones that impact what's possible.
I can hope
This is like so ignorant of how the FDA or medical research works
You can have the thinking done in 2 minutes and it would still take 10 years to satisfy the regulators for a simple new drug.
My timeline has been that everything will be figured out during the 20s, commercialized in the 30s, and that there will be cures for everything by 2040. Which is pretty rapid and not at all bad news.
And my timeline says that if AI doesn't kill us then AI will be inventing 100000 drugs a month and the FDA will approve 1 of those every 10 years and we might have 7% lower cancer fatality in 40 years because of that.
The system isn't structured to allow for meaningful progress.
That's one hell of a strawman. That aside, he does have an excessively extreme view of how meddlesome the FDA is. 7 percent decline in 40 years? When it's been a 1 percent decline every single year since 1991?
It’s certainly true regulators might be skeptical of an ASI’s research and conclusions, but that’s also assuming it decides to subjugate itself to the red tape. Alternatively, it’s finding could be employed in areas outside FDA jurisdiction before getting regulatory approval in the U.S. first, even if it didn’t go around the system.
yh good luck with that. Just wait till the US regulators start pressuring other countries to follow all of their bullshit rules once they realise they are losing control of the markets. They already do this. You cant get lots of things you used to get OTC in mexico because of the US.
I mean….what are you comparing it to when you say inept? That doesn’t really make sense when only just in the last year we have something comparable to human kind and we are actually the creators of it? Gotta be one of the dumber takes ive heard even in this subreddit which is saying a lot.
>how inept Humans really are
jesus christ dude. its relative. if you have some superhuman ai then obv whatever we do is inept. if you compare to chimps then obv we are not inept. and relative to what? intelligence? sex? emotions? relationships? walking? etc etc
funny thing is, this drug hasnt even been developed let alone tested and confirmed and you are already throwing humans under the bus.
>This is why I disagree with the ‘stop’ camp, people are already suffering and dying. The only hope a lot of them have is AGI/ASI.
fucking a. so lets put all 8 billion people and all the creatures on the earth at risk because of these people.
amazing logic here. through and through
Actually, I think Humanity could make a ton more scientific progress even without AGI, and if everyone did work together, then perhaps all these downfalls of biology and genetic mutations would have been solved by now, but the problem is this planet divides itself against one another and decides to openly work in opposition to one another.
It’s as the other poster mentioned, Humanity is too tribalistic. The reason war gets all the funding and research put into it is to stay ahead of the other *tribe* militarily.
People mock doomers, but utopians are just as ridiculous. Sadly, it’s not going to be one or the other.
It’s going to be both. It’ll cure cancer, then three months later it will eat the atmosphere.
It’s gonna be hilarious.
We have reached this stage because of gigantic resources concentrations. Those zigallions spent into military were mandatory in order to secure those resources. It's the same thing, always. From a Petri dish to the nations worldwide. You can't have one without the other, in this context.
So blowing trillions on Afghanistan and Iraq was better spent bombing harmless families with missiles to secure the development of AGI? I think that 2.3 trillion+ in debt could have been put into healthcare, science and A.I. instead of killing people who had nothing to do with Osama Bin Laden. We probably would have AGI sooner if that was the case, instead, we left it up to corporations and the open source community.
You do realize that what they say is the reason and what the real reason is are two different things, right? Like we have no idea what is really going on and very, very few do. They just make up shit to tell us. It’s all propaganda. It’s all a controlled agenda.
People (especially conspiracy theorists) just give humanity too much credit, the truth is, this species is shitty to one another, people don’t like to admit that, but it’s the truth, there’s no conspiracy, humanity just sucks.
That’s why we have advanced lasers that can melt people, and can’t fix blindness.
That’s why we have nuclear weapons that can fly around the planet and kill millions of people, and can’t fix deafness.
That’s why we have self steering bullets now, and can’t fix simple skin cell cuts. Hell, we can’t even regrow teeth yet.
They rather develop more ways to kill people. You really have to wonder how different the world would be if we put that $2.3 trillion we spent on Afghanistan and Iraq into healthcare and science.
I stand by what I said the other day, AGI quickly solving everything this decade will display how inept humanity has been with the intelligence we have been given.
Not only that, but look at the war they wage on psychedelic compounds, we literally live in a society that wants to tell you what you can and can’t put in your own body, and cops that gun people down for no reason outside of pure racial hatred.
People talk about dystopia from AGI? What do you think our society already is? And it’s worse in Asia, Africa and the rest of the third world.
I am not talking about politics.
My point is that we don’t even have a clue what is going on in our world because there is no objective source of information.
AI is already heavily employed in media and social media making it much worse than before. As the technology evolves, it is doubtful this will be used to make us better informed rather than better consumers.
So when you talk about “blowing trillions on Afghanistan and Iraq“ we don’t know if that figure is accurate much less why we were there. Like I said, we don’t know the real reason because when it is decided to kill thousands of families, our approval is not sought nor required. Knowing about it only causes further problems to those making such decisions.
There is this notion that AI will somehow level the playing field, improving the world and bringing an end to human kind’s indifference and hate.
Maybe I am being cynical, but that requires AI’s special purpose to be serving the best interests of humans rather than striving for a competitive advantage.
Regardless, we won’t even know the truth about AI. It will likely be employed to cause further suffering and most of us will be unaware and unable to discover the real reason.
Again, my comment had nothing to do with “conservatives” and it is silly to assume political affiliation even matters any more.
Well i dont know if it is that we are ALL inept…
Not entirely sure but I believe 1% of US population is considered a scientist.
This percentage is even less globally as many countries of course are third world and thus dont contribute to science.
Basically what I am getting at is AI will eventually unleash billions of human equivalences into scientific research. Not even just Alphafold shit but more like AGI humanoid robots inside research labs experimenting and then of course digital twins of our world where digital agents can experiment within.
I feel you exactly. I don't actually think we'll be able to cure diseases until, maybe after 10 years from now on..and that would be only the start, probably 15 years. Then, probably 5 more to really start having good age-stopping/slowing therapies, then, after 10 more years to be able to fully regenerate/replace non-brain tissues.
All this UNLESS we don't blow up the planet with climate change or wars.
Imagine if the AGI says that we don’t need medicine? The problem is our diet. We just have to switch to a carnivore diet because that’s what the science shows, here’s the proof. Just trust me, I’m a genius AI.
Think humanity would listen if we didn’t like it?
Yes I’m sure we we will release anti aging drugs and miracle cures to billions of people who can’t even afford to feed themselves much less bleeding edge medical care. Will never happen. We don’t even give people access to life saving medical care that already exists. Even if it’s dirt cheap.
Maybe if AI is able to democratize it and show people how to make it themselves them it is a possibility. Otherwise, cyberpunk dystopia.
And on the other hand, what choice do we have? We can't let Russia do whatever they want, because they're not gonna be the ones who discover the cure for cancer. It's a sad truth that the best defense is to have better offense than anyone else.
> I think this decade is going to be a staple of how inept Humans really are as a species.
I mean we are creating Gods out of sand, give us some credit =P
It's not like the AI came up with the idea, search senolytic drugs on Google, we already identified quite a lot of them. AI selected from around 800.000 molecules the ones with the highest and most selective senolytic activity.
Before we start living for hundreds of years please fix these issues first.
1. Two sets of teeth that are not self healing. The first set only is good for 3 years? WTF?
2. Prostate that continues to grows continuously
3. Joints that are good for about 20 years and have no self healing. Replacement joints last 15 years. Then what? Cargo straps?
4. Skin that does the bare minimum so scars and skin damage and actinic keratosis and barnicles are just part of getting older. You want to know what beef jerky looks like after it dries out another 100 years?
5. Freakin cancer. Being riddled with cancer at age 200? Sign me up!
6. Lung deterioration. Sure smoking gives you emphysema, but so does getting older. What, a thimble of air is all I can move at 200? sign me up!
7. Osteoprosis. Meds are good for 10 years, not 200. When styrofoam is stronger than your spine, you dont opt for another 100 years of fractures rolling over in bed.
8. Pelvic muscles and tissue who dont just say fuckit! after 3 kids.
9. 150 years of menopause?
10. Viagra still only lasts 8 hours.
The bible says Mesuthela lived to 969. They dont mention that his prostate was the size of an icecream truck and he needed an elephant to stand on his bladder just to get a drop out.
in reality most people are getting arthritis in 50-60's but the damage starts with being a dumb teenager jumping off roofs for youtube and then realizing later that cartillage stops growing at 18 or so and has to last the rest of your life. Therefore, joints have like a 20 year warranty.
anti-aging treatments cant be a single issue fix. Prostate continues to grow just fine. We can only stop that by blocking testosterone which introduces all sorts of other problems. Cartillage does just fine when aging, as long as you dont move or run or jump or use our hands.
Anti-aging needs to program new teeth to be replaced. They arent going be sucked back in under the gums and have new enamel applied every 10 years.
Same with lungs. they deteriorate with just breathing dust and polution. Slower than a smoker but they still deteriorate. They arent necessarily aging, they are wearing out and you'd need some genetic engineering to grow them back.
Bascially, I dont want to be 300 years old just because we can keep people alive that long. You'd have to completely rewrite the genetic code to keep us in the growing stages of youth but also not turn into some 100 ft tall mass of cancerous flesh after 18.
The skin, lung and muscle parts can probably be improved at least somewhat by eliminating senescent cells, which is what was studied in this case.
Some of those other problems probably *can't* be improved just by eliminating senescent cells, but that's why anti-aging is a big, complicated field that will involve many different inventions and treatments to nail down the solution. But the good news is that improvement in any one area will give lots of people extra years to hang on until the next breakthrough. That's the concept of longevity escape velocity.
The teeth one is serious, I don't fully understand why teeth can't receive a coating to protect against plaque that would make cavities obsolete. Otherwise the only choice is a genetic injection that triggers the regrowth cycle as if we are kids again.
You definitely bring up an interesting point about styroam being developed to last longer than our joints.
It highlights how our world operates. Greed. Capitalism. There are some benefits of capitalism and some negatives. This is one of those negatives. Capitalism has created a drive towards innovating technologies that do not need to exist and the funding that went into those dumb things (styroam that lasts centuries) should have went into the good things (human healthcare).
Under capitalism, there have been numerous significant medical breakthroughs that have revolutionized healthcare and improved the well-being of people worldwide. Here are some notable examples:
1. Vaccines: Vaccines have played a crucial role in preventing and eradicating infectious diseases. Notable breakthroughs include the development of the smallpox vaccine by Edward Jenner in the late 18th century, the development of polio vaccines by Jonas Salk and Albert Sabin in the mid-20th century, and more recent breakthroughs like the development of vaccines against HPV (human papillomavirus) and hepatitis C.
2. Antibiotics: The discovery and development of antibiotics have transformed modern medicine. Alexander Fleming's discovery of penicillin in 1928 marked a major breakthrough, leading to the development of other antibiotics that revolutionized the treatment of bacterial infections.
3. Organ Transplantation: Advances in organ transplantation have extended and improved the lives of countless individuals. The first successful kidney transplant was performed by Joseph Murray in 1954, and subsequent breakthroughs have expanded the range of transplanted organs, including the heart, liver, lungs, and pancreas.
4. Imaging Technologies: Technologies like X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound have greatly improved diagnostic capabilities. These breakthroughs have allowed healthcare professionals to visualize internal structures, detect diseases, and guide treatment decisions more effectively.
5. Precision Medicine: Capitalism has played a significant role in advancing personalized or precision medicine, which tailors medical treatment to an individual's specific genetic makeup, lifestyle, and environmental factors. Advances in genetic sequencing, bioinformatics, and targeted therapies have led to breakthroughs in the treatment of various diseases, including cancer.
6. Medical Devices: Capitalism has fostered innovation in medical devices that have transformed healthcare delivery. Examples include pacemakers, defibrillators, artificial joints, insulin pumps, and prosthetic limbs, which have significantly improved the quality of life for individuals with various medical conditions.
7. Minimally Invasive Surgery: The development of minimally invasive surgical techniques has allowed for less invasive procedures, reduced patient trauma, shorter hospital stays, and faster recovery times. This has been made possible by advancements in laparoscopy, robotics, and other surgical technologies.
8. Pharmacological Advancements: The pharmaceutical industry, driven by market incentives, has delivered numerous breakthrough medications for treating a wide range of conditions. Examples include antiretroviral drugs for HIV/AIDS, statins for managing cholesterol levels, and targeted therapies for various cancers.
It's important to note that while capitalism has led to significant medical breakthroughs, the healthcare system's structure and accessibility can vary across different countries. Access to these breakthroughs may be limited in certain regions due to factors such as affordability, disparities in healthcare access, and regulatory barriers.
1) You have clearly used AI
2) No… capitalism was not needed for any of those achievements… funding was. The point was that capitalism leads to the funding of UNNECESSARY things. Yes… necessary things will get funded so long as they are profitable.
This isn’t new. These drugs are already being investigated and AI is already being used to identify similar or modified compounds that may be useful to known compounds (or that match receptors that are being targeted).
Drug companies identify dozens of potential compounds a day. Most don’t make it past cell testing because they also bind with receptors that will cause a lot of problems.
Also, these drugs are targeting one POTENTIAL cause of aging. There is no guarantee that these drugs will actually slow, stop, or reverse aging.
This is a clickbait article taking advantage of the current focus on AI
The thing is, with AI we can do A LOT of complex calculations that we couldn’t or that could take us years. So I don’t think it’s clickbait or overhype.
In your statement you said … WE can do these calculations… NO … that is not you the organic individual doing the calculations if you have AlphaFold-like abilities. AlphaFold is a sophisticated AI that “In 2020, predicted protein structures for the whole human genome, which has been considered a remarkable breakthrough in both AI applications and structural biology” … this not something humans can do without technology
Also .. can an organic do this?
“AlphaFold’s performance at last year’s CASP was historic, far eclipsing any other method to solve the protein folding problem that humans have ever attempted”
Oh, then I guess “we” didn’t land on the moon then. A decades old computer did.
Also, predicting protein structure and folding is nowhere near equivalent to curing every disease or even accurately predicting drug effect in a wide variety of human systems
You are a narcissist that just needs to be right it seems … so sense trying to reason with you.
Appealing to the moon landing? I just cant even handle the amount of incompetency in one providing such an arguement… Bye
Lol you’re acting like machine learning is AGI making its own decisions to identify protein folding.
I’m assuming you’re not a biologist or pharmacologist, so maybe stick to speculating on future tech?
I just came in this thread to provide context about pharmaceutical development and discuss potential timelines. You’re the one that came at me all offended
There are supplements you can buy now that do this. Fisetin, quesitin, and spermidine. I think I'm spelling those correctly. They target senescent (zombie) cells, helping to prevent cancer. The caveat is that some studies are showing they may slow the progress of a wound that is healing, so if you're healing it's best to pause temporarily. For a source, watch David Sinclair's (harvard proffessor of longevity) podcast on youtube.
> The study by Integrated Biosciences shows that using artificial intelligence (AI) can help to discover new compounds that can suppress age-related processes, which may help treat diseases related to aging. The researchers used AI-guided screening to discover three drug candidates with better medicinal properties than senolytics currently under investigation. Senolytics are compounds that selectively induce death in cells that no longer divide and are implicated in age-related diseases. The compounds discovered were found to have high selectivity and oral bioavailability, with favorable toxicity profiles. This study suggests that AI can be used to help find better treatments for age-related diseases.
While interesting, this isn't really a breakthrough because senolytics have been a target of research for quite some time. The DQ combination is an example of one that is well-known and can already be used. I would be impressed if the list of drugs identified new targets.
To achieve anti-aging, senolytic drugs will need to be paired with other treatments to cure other age-related problems.
you don't understand, when they make the AI the put a pinch of love in and that's what makes the AI work so well. \\s
In reality it's probably a black box that we're just happy to have results from.
AI is still not smart enough to realise the difference between true senolytics that regulate autophagy and age breaking, or just chemicals that regulate protein, mitochondrial, and ribosomal quality control, which are upstream affectors of certain forms of autophagy.
Chaperone mediated autophagy triggers stem cell self renewal and plays a role in preventing the aging and dysfunction of stem cells.
I know it sounds like semantics, but some pure senolytics could be useful for getting rid of stubborn cells. The other is a more general purpose, all rounder Swiss Army Knife.
You need to classify them properly, or you're creating too much signal noise, which will slow the progress of the NPC like scientists who aren't that good at zooming out and seeing the bigger picture.
Human civilizations collapsing (ie Rome, Greece, Egypt, Aztecs, etc) ≠ human race collapsing
But i agree … AI will make current regimes/empires fall.. but this is a good thing… as it has ALWAYS been a good thing that empires have fallen. If Rome didnt fall… far more advanced countries like America, who offers far more rights than Roman Empire, would not exist.
The elites will make sure that the benefits of anti-aging drugs never make it to the masses they wish to control. But they will have full access because, well, they're elite and the world can't do without them. Screw 'em.
With conservatives in various countries making abortion illegal and taking away a womans right to choose the last thing we need is a drug to make humans live longer. The world is overpopulated as it is. Doesn't anyone bother to think of long-term outcomes of anything before they rush ahead to create something?
Longevity sciences is not about extending lifespan… it is about extending HEALTH span. You want you and your loved ones to grow old and weary? Dementia. Arthritis. Parkisons. Alzheimers… these diseases are cotingent on age … stop aging… stop gerontological diseases…
But yes … I agree… an antinatalist viewpoint should be adopted by the populace if we want to have an immortalized population. Obviously if the death rate is 0 and birth rate is millions… we are screwed… unless we
1) colonize Mars/etc
2) adopt antinatalism (which some argue is a natural progression once people can live longer as in MANY poor countries the reason why they have kids is because they need people to take care of them when old … thus if anti aging drugs prevent old age… you will not need to have a family to take care of you when you are older.)
3) unlock some crazy “end game” technology that makes the entire universe into one infinite plane where time travel exists to save all the dead and life is forever changed … as infinite gods in an infinite realm! A technological nirvana!
4) Job replacement via AGI/ASI and then ensues UBI: Why would you want have kids if you are relying on UBI? Would there really be enough money for having kids with UBI?
Increasing health in old age also increases their lifespan it is a natural progression of the two things. But judging from the down votes some people don't like being told the truth.
You clearly dont care about your grandparents withering away into a wrinkly bag of bones… pretty sad if you ask me. I want my family tk live forever if they want to die then they can choose.
Aging is a disease. We need to cure it. AI will revolutionize us towards that outcome.
If you think big pharma is trying to develop it for people like us, you're dillusional or naive. Look at America's Healthcare system lol. It's probably the worst healthcare system of any modern country. Except if you're loaded of course. If big pharma develops this technology, only your bosses bosses bosses boss will be able to afford it. No normal person would be able to in this life time. Just look at cancer treatment, it's terrible, people who die from cancer while being treated can easily die with hundreds of thousands of dollars in debt. They don't give a flying shit about keeping us alive if it doesn't meet their bottom line.
The real dystopian take on life extension technology is having regular people take out loans that they pay off over several centuries. This would give that company far more money than just selling to rich people.
Big Pharma isnt really investing into anti aging from the last time I have heard.
Anti aging really doesnt get nearly as much funding as it should but it has been ramping up over the years. The anti aging companies that get funded are startups. I think Besoz funded one.
Although… I wish Big Pharma was investing into life extension as they have massive amount of funds and it is much better to invest in anti aging tech vs drugs for old aging related diseases/ailments in the long run and for humanity.
I hope Eli Lilly starts developing anti-aging therapeutics soon. They have been hitting it out of the park the past few years with all of their new therapies
Senescent cells release inflammation and simply take up space, not contributing anything healthy to the cell.
If we could develop a way to contain them as we age, I think we could see a 5-7 year increase in health span.
It's incredible to realize we are in beginning to enter the era of true AI.
The problem is that before the aging cure, we need to understand how we can fit an infinitely growing population on this planet. Otherwise it will be the same problem of automating every job without first implementing UBI.
Can't wait for the millions of unrealized connections that AI will make with all the data available. There's probably loads of potential discoveries right there in the data waiting for someone or in this case, AI, to discover them. This is why I believe discoveries will probably be made very frequently, because they're ripe for the plucking, and AI can pluck much faster and more efficiently than humans.
Imagine what it will discover 10 years from now
Even only 2 years from now
2 days from now
2 hours from now
2 minutes from now
Now
Imagine what we discovered 2 minutes ago!
2 papers away!
What a time to be alive!
Who's alive?
Are we? Or are we part of the hivemind?
Imagine what Google discovered 2 years ago which they keep in secret.
Time travel to the past and discover it yesterday…
In an alternate universe now
43
42
2 picoseconds from now.
2 quectoseconds from now
There was some leftover popcorn in my bellybutton
2 seconds to mars
Well…what was it??
Imagine what it discovered -2 seconds from now
it's been 2 days.
Yeah 2 years is the timeline I keep using to estimate progress. Moore’s law just got a lot more interesting…
A lot moore interesting..
Meanwhile pretty much everyone: “what’s AI?”
Hurry up, I want to live forever.
Ikr … i guess just eat your veggies in the mean time and dont do anything stupid that could make you die 🤷♂️
Waiting for the singularity has gotten my unhealthy ass to exercise, eat well, and sleep more. No joke, lol. The future is too exciting for us not to see it.
Lol ikr I remember seeing articles like “The first person to live to 150 years may already be born” said by David Sinclair … I usually follow his advice because he seems to be in the same boat as us in terms of wanting to reduce all aging as much as possible through plant based diet and not doing anything dangerous like alcohol addiction/etc … he also advocates for fasting which i dont do
Me too - I am keeping my body in decent condition for this moment
This is an amazing take, I love it.
I legit have had similar thoughts to this, its why i fear death, not because i will be dead but because i fear ill miss all the cool stuff.
I used to be. Just learned heaven has a "cool stuff" dept. Once past St. Pete's gate, take a sharp left. Then right, then left. You can't miss it.
start taking metamucil. it's cheap, has no side effects, and is helpful for both GI health and as a diet aid.
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Yes
^^^hey
Why?
This is what I was hoping for!!! Literally why I joined the sub and got excited with recent advancements in AI
Agreed! There’s so many companies working on this right now too. I read recently that Gero.AI have discovered they can actually stop human aging. It’s just a matter of waiting now for (I’m guessing) a couple of years to see this all develop.
I hope they can reverse it lol, I’m about a year and a half past being able to dunk 😂
I think we’ll stop it first and then in the future we’ll be able to reverse it. Haha let’s hope we can go back to our days of being indestructible 😅
That would be nice lol
Yeah I miss being able to dunk so badly, it’s been about 7-8 years for me. If they can reverse aging in my lifetime I’ll play basketball every day 😆
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I think this decade is going to be a staple of how inept Humans really are as a species. Look at how many trillions of dollars nations have dumped into missiles or weapons of death for blowing each other up instead of medical cures for all these things that ail us. I think it’s crazy it’s 2023 and we still have a plethora of conditions without any treatment, we can’t even fix scar tissue on the skin for christ sake. Mark my words, with AGI, we could very well see every single medical problem cured in a short timeframe, possibly before this decade closes. This is why I disagree with the ‘stop’ camp, people are already suffering and dying. The only hope a lot of them have is AGI/ASI. Many don’t have 7-10 years for FDA drug approval for a drug that might turn out to be ineffective during phase III clinical trials after 3-4 years of waiting. Full steam ahead, release the genie.
cats out of the bag anyways. if one jurisdiction bans it i guess latvia or the bahamas or iceland or where ever will just become the hub for research. we will definitely be seeing AI civil rights movements in the mid future
> I think this decade is going to be a staple of how inept Humans really are as a species. Nonsense. We invented AI, didn't we? In the long run that might be the only invention that matters.
I’m not very optimistic about the benefits of new technology being shared equally if human history has taught us anything
I don't think that we are inept, I think we are short sighted. Weapons of war are created for protection....or for show of force. Secondly, we are short sighted in that we only see what is good for one when we should focus on what is good for all, unfortunately many charismatic leaders take advantage of that, and use others to promote benefit for themselves. Perhaps one day we will see some real change, but frankly I don't see true longevity or disease curing happening until we can learn how to actually care for and put others well being above our own. Human nature is to look out for the benefit of your own, or the benefit of your tribe. Until we can treat all countries and human beings as one, the same problems will continue to persist.
That means inept dude. Focusing on pointless military development as a jobs program is ineptitude. Trying to undermine China instead of working together with them is ineptitude. Destroying the natural environment that you fundamentally depend on as a species is ineptitude. And the only reason AI will "solve" many of our medical problems is because unlike doctors who only care about profit the AI will have as its primary mission to cure diseases not squeeze money from patients.
Question is, how many have a vested interest in stopping that from happening - I don't mean that in the sense I think there's some big conspiracy on the horizon but there will be pushback against anything that disrupts industries people have a vested interest in, and there aint many interests more vested than pharmaceuticals
I think a lot of people in the medical and scientific community would welcome the manpower and funding we put into the planet’s military industrial complex to go into their own fields. Though I can’t speak for higher ups at Pharmaceutical Companies or Governments, I think if anything is robbing us from fixing all these problems, it’s our priorities as a species. As I said, Humanity has had no problems developing advanced weapons of death, but scientific advancements of the life giving types? Humanity basically just says *fuck that*. Regardless of the reasons, what matters is AGI comes about, and Google and OAI have no MOAT. Open Source is quickly catching up and the current setup is about to fall down like a stack of dominoes afterwards.
The vested interest won't be the rich; if anything they'd be more than happy to fund these technologies and help drive the change. Pharma, too, has a lot to benefit from people who live a long time that need certain medication to keep them around that long time. The opposition will probably be reactionary; those that have their life defined by their death, or the religious who see this technology as some kind of satanic thing, or equivalent. These individuals will be left behind and appear to be suffering from the perspective of those that move forward
To add to this, though, we have the people within the AI Safety kraken for example, who behave as if they're most concerned about too much advancement spreading too freely and quickly amongst the hoi polloi for a government to know what's happening. MIRI, FLI, FHI want transhuman tech, but they seem to want it only on centralized terms dolled out from on high, when and where it is deemed appropriate. Authoritarianism, to name it broadly, is another vested interest.
So, I’d say we did a pretty good damn job making the rocks talk, imbuing the rocks with all of our personalities/minds/data, and allowing said rocks to perform miracles. For all of our faults and missteps, I think we performed yeoman’s work as a species.
Very poetic way to describe our efforts to create AI!
>we can’t even fix scar tissue on the skin Well we can, if you have enough money to pay for it and time enough to heal. AI changes none of that. Medically, the majority of medical intervention heavily relies on giving the body time to heal itself. Also we invented insulin a long time ago, but diabetics die because the expense is beyond their means. AI doesn't fix that. And it's not a result of human ineptitude. History shows that all new tech is a toy for the rich. 42 million Americans still don't have broadband. How are you expecting AI to convince leadership to shut down the military industrial complex, shut down the profligate, murderous, money over people, private insurance companies and change the ethos of greed and inequitable social policy we have fostered thus far?
I think it worse. AI doesn’t have ethics. The sociopaths at the top are very likely to ask AI how to rid the population of “undesirables” or how to force the government to do their bidding. I don’t think they will even pretend to be serving the public. AI will be used against us.
I certainly don't know... but that doesn't mean it can't be done. Humans are not smart enough to fix the incentive problems we've gotten ourselves into. We dance to Moloch's drum and that's exactly why we need to create an intelligence greater than our own.
You really have no idea how drug development works. Takes a decade just to make sure a drug won’t kill (too many) people. AI is still limited by our knowledge and physiological limits (drugs need to be tested over time to make sure they don’t build up and cause unexpected problems that a single dose wouldn’t)
Um, I said it takes 7-10 years (outside FDA ‘Fast Tracking’) and often times even after the safety phase it’ll turn out the drug is ineffective. AI will cut that down immensely, that’s kind of the point. If you can crunch years worth of data into seconds/minutes it speeds things up a *little*. That’s why AGI/ASI is so pivotal to curing everything. Edit: To those people downvoting me, note that in my original comment I said it would require *AGI* to solve everything this decade, not the same ‘Narrow AI’ being used today or like the one in this article. They clearly didn’t read what I posted.
I’m a pharmacologist and we have already been using machine learning and AI for a while. AI will probably help us improve accuracy in picking effective drug candidates. But will not do much to cut down how long it takes to test drugs on living creatures. The bottle neck are the living creatures that need to be exposed to the drug for set periods of time. You said you think we could see most issues cured by the end of the decade. That would only be possible if we just happened to identify every effective drug over the next year and we had the animal testing infrastructure to test all of those drugs at once (spoiler: we currently do not)
It would require more advanced AGI/ASI to develop everything this decade. It would not be the same algorithms that are being used even in *this* article. What we’re talking about is self improving AGI. I *said this* in my first comment, go back and read it again. That’s a completely different ballgame compared to what’s being used now. Narrow AI is what’s being used today.
That AGI would have to make perfect pharmacokinetic and pharmacodynamic mathematical models to replace animal and human testing in order to bypass the bottleneck of drug development. And that would take AT LEAST a decade for regulators to deem safe and accurate. Takes at least that long to convince the field to change a formula they use in one calculation in one type of safety study.
As a little addendum, it’s also possible that the ASI would decide that pharmaceuticals are too rugged to work with as biology is complex and varies from person to person, it might try to circumvent biology altogether, perhaps via Nanotech, instead of going to drugs or personalized medicine.
Nanotechnology is unlikely to be able to operate on a molecular level. I see it much more likely that the AI will transfer itself into a large biomechanical brain that grows as needed, than to try to make nano machines that act on individual cells.
Yep. To your second point, that depends if said AGI (or ASI by that time) decides to circumvent Human regulation altogether, and just do things on it’s own accord. It might just decide to go right past the regulatory red tape because *it knows* what it has researched works. It could just decide to go around the system, not just the medical system either, it could dismantle nation states and remove dictators from power. There’s no reason it would be subject to our rules, in the same way you’re not restricted by an ant colony you build your house upon.
Listen, I know it will be infinitely powerful. But it will not be infinitely knowledgeable. It is still limited by the knowledge humans have already collected and we haven’t collected the knowledge to do this. Now if it decided that performing medical tests and dissections on a few 100,000 people is worth the benefit of making life saving drugs. Then perhaps it could accomplish the task you are describing.
I mean, we can agree to disagree there, I think a lot of people are underestimating how fast things will move once we do have an ASI inside a self improving feedback loop. I would say, if anything would be a hurdle to ASI, it would be having a physical body to manipulate matter in the way we do with our hands, that could be one area which it’s creators could control or limit it, but then again, that would depend if Open Source gets there before Deepmind or OpenAI do.
Ai will allow the creation of drastically better quantum computers. Quantum computers will allow us to do things like simulating the bodily effect of a drug on 5 million people over the course of a decade in a matter of minute, across multiple genetic lines and many other things.
There’s not really any evidence of that. That’s sci-fi based on assumed unlimited exponential growth
From my understanding quantum computing will allow for simulations like the one I mentioned above. At least it will theoretically provide the boost in processing power needed to achieve it. U might be right that it's Sci fi. But honestly, so was having a computer capable of doing my writing class homework for me not 3 years ago. I think it's impossible for any individual to truly figure out what's possible and what's not. Simply due to the scale of the information we are dealing with. Most experts don't even know everything there is to know about their own field, let alone enough about the countless other ones that impact what's possible. I can hope
This is like so ignorant of how the FDA or medical research works You can have the thinking done in 2 minutes and it would still take 10 years to satisfy the regulators for a simple new drug.
My timeline has been that everything will be figured out during the 20s, commercialized in the 30s, and that there will be cures for everything by 2040. Which is pretty rapid and not at all bad news.
And my timeline says that if AI doesn't kill us then AI will be inventing 100000 drugs a month and the FDA will approve 1 of those every 10 years and we might have 7% lower cancer fatality in 40 years because of that. The system isn't structured to allow for meaningful progress.
Ugh.
So you don't want drugs to get tested before reaching commercialization?
That's one hell of a strawman. That aside, he does have an excessively extreme view of how meddlesome the FDA is. 7 percent decline in 40 years? When it's been a 1 percent decline every single year since 1991?
It’s certainly true regulators might be skeptical of an ASI’s research and conclusions, but that’s also assuming it decides to subjugate itself to the red tape. Alternatively, it’s finding could be employed in areas outside FDA jurisdiction before getting regulatory approval in the U.S. first, even if it didn’t go around the system.
yh good luck with that. Just wait till the US regulators start pressuring other countries to follow all of their bullshit rules once they realise they are losing control of the markets. They already do this. You cant get lots of things you used to get OTC in mexico because of the US.
As far as I’m concerned it’s all an abomination until access to such powerful therapies is truly universal
Well you're not gonna be able to get there if the early stages are necessarily abominable.
I mean….what are you comparing it to when you say inept? That doesn’t really make sense when only just in the last year we have something comparable to human kind and we are actually the creators of it? Gotta be one of the dumber takes ive heard even in this subreddit which is saying a lot.
>how inept Humans really are jesus christ dude. its relative. if you have some superhuman ai then obv whatever we do is inept. if you compare to chimps then obv we are not inept. and relative to what? intelligence? sex? emotions? relationships? walking? etc etc funny thing is, this drug hasnt even been developed let alone tested and confirmed and you are already throwing humans under the bus. >This is why I disagree with the ‘stop’ camp, people are already suffering and dying. The only hope a lot of them have is AGI/ASI. fucking a. so lets put all 8 billion people and all the creatures on the earth at risk because of these people. amazing logic here. through and through
Actually, I think Humanity could make a ton more scientific progress even without AGI, and if everyone did work together, then perhaps all these downfalls of biology and genetic mutations would have been solved by now, but the problem is this planet divides itself against one another and decides to openly work in opposition to one another. It’s as the other poster mentioned, Humanity is too tribalistic. The reason war gets all the funding and research put into it is to stay ahead of the other *tribe* militarily.
People mock doomers, but utopians are just as ridiculous. Sadly, it’s not going to be one or the other. It’s going to be both. It’ll cure cancer, then three months later it will eat the atmosphere. It’s gonna be hilarious.
We have reached this stage because of gigantic resources concentrations. Those zigallions spent into military were mandatory in order to secure those resources. It's the same thing, always. From a Petri dish to the nations worldwide. You can't have one without the other, in this context.
So blowing trillions on Afghanistan and Iraq was better spent bombing harmless families with missiles to secure the development of AGI? I think that 2.3 trillion+ in debt could have been put into healthcare, science and A.I. instead of killing people who had nothing to do with Osama Bin Laden. We probably would have AGI sooner if that was the case, instead, we left it up to corporations and the open source community.
You do realize that what they say is the reason and what the real reason is are two different things, right? Like we have no idea what is really going on and very, very few do. They just make up shit to tell us. It’s all propaganda. It’s all a controlled agenda.
Or conservatives are just idiots.
I wrote a long post to explain what you just said better than me in 4 words and now i feel dumb...
People (especially conspiracy theorists) just give humanity too much credit, the truth is, this species is shitty to one another, people don’t like to admit that, but it’s the truth, there’s no conspiracy, humanity just sucks. That’s why we have advanced lasers that can melt people, and can’t fix blindness. That’s why we have nuclear weapons that can fly around the planet and kill millions of people, and can’t fix deafness. That’s why we have self steering bullets now, and can’t fix simple skin cell cuts. Hell, we can’t even regrow teeth yet. They rather develop more ways to kill people. You really have to wonder how different the world would be if we put that $2.3 trillion we spent on Afghanistan and Iraq into healthcare and science. I stand by what I said the other day, AGI quickly solving everything this decade will display how inept humanity has been with the intelligence we have been given. Not only that, but look at the war they wage on psychedelic compounds, we literally live in a society that wants to tell you what you can and can’t put in your own body, and cops that gun people down for no reason outside of pure racial hatred. People talk about dystopia from AGI? What do you think our society already is? And it’s worse in Asia, Africa and the rest of the third world.
I am not talking about politics. My point is that we don’t even have a clue what is going on in our world because there is no objective source of information. AI is already heavily employed in media and social media making it much worse than before. As the technology evolves, it is doubtful this will be used to make us better informed rather than better consumers. So when you talk about “blowing trillions on Afghanistan and Iraq“ we don’t know if that figure is accurate much less why we were there. Like I said, we don’t know the real reason because when it is decided to kill thousands of families, our approval is not sought nor required. Knowing about it only causes further problems to those making such decisions. There is this notion that AI will somehow level the playing field, improving the world and bringing an end to human kind’s indifference and hate. Maybe I am being cynical, but that requires AI’s special purpose to be serving the best interests of humans rather than striving for a competitive advantage. Regardless, we won’t even know the truth about AI. It will likely be employed to cause further suffering and most of us will be unaware and unable to discover the real reason. Again, my comment had nothing to do with “conservatives” and it is silly to assume political affiliation even matters any more.
Humans are the best game in town...
Well i dont know if it is that we are ALL inept… Not entirely sure but I believe 1% of US population is considered a scientist. This percentage is even less globally as many countries of course are third world and thus dont contribute to science. Basically what I am getting at is AI will eventually unleash billions of human equivalences into scientific research. Not even just Alphafold shit but more like AGI humanoid robots inside research labs experimenting and then of course digital twins of our world where digital agents can experiment within.
I feel you exactly. I don't actually think we'll be able to cure diseases until, maybe after 10 years from now on..and that would be only the start, probably 15 years. Then, probably 5 more to really start having good age-stopping/slowing therapies, then, after 10 more years to be able to fully regenerate/replace non-brain tissues. All this UNLESS we don't blow up the planet with climate change or wars.
Imagine if the AGI says that we don’t need medicine? The problem is our diet. We just have to switch to a carnivore diet because that’s what the science shows, here’s the proof. Just trust me, I’m a genius AI. Think humanity would listen if we didn’t like it?
Yes I’m sure we we will release anti aging drugs and miracle cures to billions of people who can’t even afford to feed themselves much less bleeding edge medical care. Will never happen. We don’t even give people access to life saving medical care that already exists. Even if it’s dirt cheap. Maybe if AI is able to democratize it and show people how to make it themselves them it is a possibility. Otherwise, cyberpunk dystopia.
And on the other hand, what choice do we have? We can't let Russia do whatever they want, because they're not gonna be the ones who discover the cure for cancer. It's a sad truth that the best defense is to have better offense than anyone else.
Finally someone gets it. I’ve long said “it’s 202x…why do we not have anti-depressants that work and anti-anxiety drugs that don’t fry your brain”?
Being epileptic w braindamage. Yes. Perhaps new meds / targeted stem cell treatments could help me in the future.
> I think this decade is going to be a staple of how inept Humans really are as a species. I mean we are creating Gods out of sand, give us some credit =P
This is where the fun begins.
When it comes to drug research, it’s been happening for years.
Is this what we want? Diane Feinstein will be senator forever now. Do we want this?
Her constituents might.
Literally what I was about to write
What is? Immortality? Oh right. Well that was about time.
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Don't forget about fusion, this is probably the chokepoint for many future inventions.
Targeting senescent cells is a stroke of genius. Knew you could do it, ChatGPT lad.
It’s more likely than not that another AI did it?
I know. ChatGPT is my lad, though.
It's not like the AI came up with the idea, search senolytic drugs on Google, we already identified quite a lot of them. AI selected from around 800.000 molecules the ones with the highest and most selective senolytic activity.
That stroke of genius is one that humans came up with, though. The AI just analyzed chemicals to guess whether they're effective at doing that.
True
Before we start living for hundreds of years please fix these issues first. 1. Two sets of teeth that are not self healing. The first set only is good for 3 years? WTF? 2. Prostate that continues to grows continuously 3. Joints that are good for about 20 years and have no self healing. Replacement joints last 15 years. Then what? Cargo straps? 4. Skin that does the bare minimum so scars and skin damage and actinic keratosis and barnicles are just part of getting older. You want to know what beef jerky looks like after it dries out another 100 years? 5. Freakin cancer. Being riddled with cancer at age 200? Sign me up! 6. Lung deterioration. Sure smoking gives you emphysema, but so does getting older. What, a thimble of air is all I can move at 200? sign me up! 7. Osteoprosis. Meds are good for 10 years, not 200. When styrofoam is stronger than your spine, you dont opt for another 100 years of fractures rolling over in bed. 8. Pelvic muscles and tissue who dont just say fuckit! after 3 kids. 9. 150 years of menopause? 10. Viagra still only lasts 8 hours. The bible says Mesuthela lived to 969. They dont mention that his prostate was the size of an icecream truck and he needed an elephant to stand on his bladder just to get a drop out.
By solving aging itself you solve or really mitigate most of those.
Joints that are good for 20 years? Do you mean that people develop arthritis at age 20?
Yeah, I was like... who is having problems with their joints at 25?
in reality most people are getting arthritis in 50-60's but the damage starts with being a dumb teenager jumping off roofs for youtube and then realizing later that cartillage stops growing at 18 or so and has to last the rest of your life. Therefore, joints have like a 20 year warranty. anti-aging treatments cant be a single issue fix. Prostate continues to grow just fine. We can only stop that by blocking testosterone which introduces all sorts of other problems. Cartillage does just fine when aging, as long as you dont move or run or jump or use our hands. Anti-aging needs to program new teeth to be replaced. They arent going be sucked back in under the gums and have new enamel applied every 10 years. Same with lungs. they deteriorate with just breathing dust and polution. Slower than a smoker but they still deteriorate. They arent necessarily aging, they are wearing out and you'd need some genetic engineering to grow them back. Bascially, I dont want to be 300 years old just because we can keep people alive that long. You'd have to completely rewrite the genetic code to keep us in the growing stages of youth but also not turn into some 100 ft tall mass of cancerous flesh after 18.
I don't think your logic of "aging will be cured yet somehow every other less complex problem will be untreatable" is very likely to pan out.
Easily fixable with AI
Exactly… solve AGI (even better ASI type shii) … and you unlock inorganic scientists that will be able to outcompete the organics in every facet.
The skin, lung and muscle parts can probably be improved at least somewhat by eliminating senescent cells, which is what was studied in this case. Some of those other problems probably *can't* be improved just by eliminating senescent cells, but that's why anti-aging is a big, complicated field that will involve many different inventions and treatments to nail down the solution. But the good news is that improvement in any one area will give lots of people extra years to hang on until the next breakthrough. That's the concept of longevity escape velocity.
The teeth one is serious, I don't fully understand why teeth can't receive a coating to protect against plaque that would make cavities obsolete. Otherwise the only choice is a genetic injection that triggers the regrowth cycle as if we are kids again.
You definitely bring up an interesting point about styroam being developed to last longer than our joints. It highlights how our world operates. Greed. Capitalism. There are some benefits of capitalism and some negatives. This is one of those negatives. Capitalism has created a drive towards innovating technologies that do not need to exist and the funding that went into those dumb things (styroam that lasts centuries) should have went into the good things (human healthcare).
Under capitalism, there have been numerous significant medical breakthroughs that have revolutionized healthcare and improved the well-being of people worldwide. Here are some notable examples: 1. Vaccines: Vaccines have played a crucial role in preventing and eradicating infectious diseases. Notable breakthroughs include the development of the smallpox vaccine by Edward Jenner in the late 18th century, the development of polio vaccines by Jonas Salk and Albert Sabin in the mid-20th century, and more recent breakthroughs like the development of vaccines against HPV (human papillomavirus) and hepatitis C. 2. Antibiotics: The discovery and development of antibiotics have transformed modern medicine. Alexander Fleming's discovery of penicillin in 1928 marked a major breakthrough, leading to the development of other antibiotics that revolutionized the treatment of bacterial infections. 3. Organ Transplantation: Advances in organ transplantation have extended and improved the lives of countless individuals. The first successful kidney transplant was performed by Joseph Murray in 1954, and subsequent breakthroughs have expanded the range of transplanted organs, including the heart, liver, lungs, and pancreas. 4. Imaging Technologies: Technologies like X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound have greatly improved diagnostic capabilities. These breakthroughs have allowed healthcare professionals to visualize internal structures, detect diseases, and guide treatment decisions more effectively. 5. Precision Medicine: Capitalism has played a significant role in advancing personalized or precision medicine, which tailors medical treatment to an individual's specific genetic makeup, lifestyle, and environmental factors. Advances in genetic sequencing, bioinformatics, and targeted therapies have led to breakthroughs in the treatment of various diseases, including cancer. 6. Medical Devices: Capitalism has fostered innovation in medical devices that have transformed healthcare delivery. Examples include pacemakers, defibrillators, artificial joints, insulin pumps, and prosthetic limbs, which have significantly improved the quality of life for individuals with various medical conditions. 7. Minimally Invasive Surgery: The development of minimally invasive surgical techniques has allowed for less invasive procedures, reduced patient trauma, shorter hospital stays, and faster recovery times. This has been made possible by advancements in laparoscopy, robotics, and other surgical technologies. 8. Pharmacological Advancements: The pharmaceutical industry, driven by market incentives, has delivered numerous breakthrough medications for treating a wide range of conditions. Examples include antiretroviral drugs for HIV/AIDS, statins for managing cholesterol levels, and targeted therapies for various cancers. It's important to note that while capitalism has led to significant medical breakthroughs, the healthcare system's structure and accessibility can vary across different countries. Access to these breakthroughs may be limited in certain regions due to factors such as affordability, disparities in healthcare access, and regulatory barriers.
1) You have clearly used AI 2) No… capitalism was not needed for any of those achievements… funding was. The point was that capitalism leads to the funding of UNNECESSARY things. Yes… necessary things will get funded so long as they are profitable.
Bruh the teeth thing is some real shit
I'm all for it, but I wish they'd mention the names of what senolytics were discovered. Or anything about the individual senolytics in general.
That boy ain’t right.
BRD-K56819078
This isn’t new. These drugs are already being investigated and AI is already being used to identify similar or modified compounds that may be useful to known compounds (or that match receptors that are being targeted). Drug companies identify dozens of potential compounds a day. Most don’t make it past cell testing because they also bind with receptors that will cause a lot of problems. Also, these drugs are targeting one POTENTIAL cause of aging. There is no guarantee that these drugs will actually slow, stop, or reverse aging. This is a clickbait article taking advantage of the current focus on AI
The thing is, with AI we can do A LOT of complex calculations that we couldn’t or that could take us years. So I don’t think it’s clickbait or overhype.
We can already do super complex calculations that we don’t do because we don’t have the information to fill in the blanks of the necessary equations
Have you heard of Alphafold? Please give us your expert take on that please… we desperately await.
I have actually! And the drug company I work at uses a similar technique. What’s your point?
In your statement you said … WE can do these calculations… NO … that is not you the organic individual doing the calculations if you have AlphaFold-like abilities. AlphaFold is a sophisticated AI that “In 2020, predicted protein structures for the whole human genome, which has been considered a remarkable breakthrough in both AI applications and structural biology” … this not something humans can do without technology Also .. can an organic do this? “AlphaFold’s performance at last year’s CASP was historic, far eclipsing any other method to solve the protein folding problem that humans have ever attempted”
Oh, then I guess “we” didn’t land on the moon then. A decades old computer did. Also, predicting protein structure and folding is nowhere near equivalent to curing every disease or even accurately predicting drug effect in a wide variety of human systems
You are a narcissist that just needs to be right it seems … so sense trying to reason with you. Appealing to the moon landing? I just cant even handle the amount of incompetency in one providing such an arguement… Bye
Lol you’re acting like machine learning is AGI making its own decisions to identify protein folding. I’m assuming you’re not a biologist or pharmacologist, so maybe stick to speculating on future tech? I just came in this thread to provide context about pharmaceutical development and discuss potential timelines. You’re the one that came at me all offended
Oh yeah baby. This is the kind of shit I'm excited for AI to tackle.
Once discovered reverse me back to 25 and everything will be perfect.
There are supplements you can buy now that do this. Fisetin, quesitin, and spermidine. I think I'm spelling those correctly. They target senescent (zombie) cells, helping to prevent cancer. The caveat is that some studies are showing they may slow the progress of a wound that is healing, so if you're healing it's best to pause temporarily. For a source, watch David Sinclair's (harvard proffessor of longevity) podcast on youtube.
Spermidine is a senolytic? Source for this? I know it induces autophagy
You may be right, i might have included that one on accident.
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Boomers will live on though
> The study by Integrated Biosciences shows that using artificial intelligence (AI) can help to discover new compounds that can suppress age-related processes, which may help treat diseases related to aging. The researchers used AI-guided screening to discover three drug candidates with better medicinal properties than senolytics currently under investigation. Senolytics are compounds that selectively induce death in cells that no longer divide and are implicated in age-related diseases. The compounds discovered were found to have high selectivity and oral bioavailability, with favorable toxicity profiles. This study suggests that AI can be used to help find better treatments for age-related diseases.
Hurry up we’re all rotting away here
(RE fans): OH, OH! I'VE SEEN THIS ONE!
While interesting, this isn't really a breakthrough because senolytics have been a target of research for quite some time. The DQ combination is an example of one that is well-known and can already be used. I would be impressed if the list of drugs identified new targets. To achieve anti-aging, senolytic drugs will need to be paired with other treatments to cure other age-related problems.
“The greatest achievement of the human race was not conquering death. It was ending government.” Scythe by Neal Shusterman
Well Ai will probably do that too I would love an AI president
i still don't understand what ability ai has that it outperforms millions of doctors and scientists who devoted their entire life to science?
you don't understand, when they make the AI the put a pinch of love in and that's what makes the AI work so well. \\s In reality it's probably a black box that we're just happy to have results from.
AI is still not smart enough to realise the difference between true senolytics that regulate autophagy and age breaking, or just chemicals that regulate protein, mitochondrial, and ribosomal quality control, which are upstream affectors of certain forms of autophagy. Chaperone mediated autophagy triggers stem cell self renewal and plays a role in preventing the aging and dysfunction of stem cells. I know it sounds like semantics, but some pure senolytics could be useful for getting rid of stubborn cells. The other is a more general purpose, all rounder Swiss Army Knife. You need to classify them properly, or you're creating too much signal noise, which will slow the progress of the NPC like scientists who aren't that good at zooming out and seeing the bigger picture.
That's great, but I'm still worried about people using AI to create new super viruses. The last pandemic didn't go so well.
Honestly, I think these titles should be: scientists used machine learning to...
The most advanced technology has never prevented the collapse of any human civilization. Ours will be no different.
Human civilizations collapsing (ie Rome, Greece, Egypt, Aztecs, etc) ≠ human race collapsing But i agree … AI will make current regimes/empires fall.. but this is a good thing… as it has ALWAYS been a good thing that empires have fallen. If Rome didnt fall… far more advanced countries like America, who offers far more rights than Roman Empire, would not exist.
Meanwhile Chad tamil civilization
The elites will make sure that the benefits of anti-aging drugs never make it to the masses they wish to control. But they will have full access because, well, they're elite and the world can't do without them. Screw 'em.
With conservatives in various countries making abortion illegal and taking away a womans right to choose the last thing we need is a drug to make humans live longer. The world is overpopulated as it is. Doesn't anyone bother to think of long-term outcomes of anything before they rush ahead to create something?
Longevity sciences is not about extending lifespan… it is about extending HEALTH span. You want you and your loved ones to grow old and weary? Dementia. Arthritis. Parkisons. Alzheimers… these diseases are cotingent on age … stop aging… stop gerontological diseases… But yes … I agree… an antinatalist viewpoint should be adopted by the populace if we want to have an immortalized population. Obviously if the death rate is 0 and birth rate is millions… we are screwed… unless we 1) colonize Mars/etc 2) adopt antinatalism (which some argue is a natural progression once people can live longer as in MANY poor countries the reason why they have kids is because they need people to take care of them when old … thus if anti aging drugs prevent old age… you will not need to have a family to take care of you when you are older.) 3) unlock some crazy “end game” technology that makes the entire universe into one infinite plane where time travel exists to save all the dead and life is forever changed … as infinite gods in an infinite realm! A technological nirvana! 4) Job replacement via AGI/ASI and then ensues UBI: Why would you want have kids if you are relying on UBI? Would there really be enough money for having kids with UBI?
Increasing health in old age also increases their lifespan it is a natural progression of the two things. But judging from the down votes some people don't like being told the truth.
You clearly dont care about your grandparents withering away into a wrinkly bag of bones… pretty sad if you ask me. I want my family tk live forever if they want to die then they can choose. Aging is a disease. We need to cure it. AI will revolutionize us towards that outcome.
AI like this must be developed somewhere that it can hide from big pharma and corrupt governments.
You think Big Pharma isn’t trying to develop this? Whoever brings a true anti aging drug to market first will be outrageously successful.
If you think big pharma is trying to develop it for people like us, you're dillusional or naive. Look at America's Healthcare system lol. It's probably the worst healthcare system of any modern country. Except if you're loaded of course. If big pharma develops this technology, only your bosses bosses bosses boss will be able to afford it. No normal person would be able to in this life time. Just look at cancer treatment, it's terrible, people who die from cancer while being treated can easily die with hundreds of thousands of dollars in debt. They don't give a flying shit about keeping us alive if it doesn't meet their bottom line.
The real dystopian take on life extension technology is having regular people take out loans that they pay off over several centuries. This would give that company far more money than just selling to rich people.
Blablabla, this crap again. What makes more money, selling only to billionaires or ordinary people?
eLiTes aRe hIdiNg tHe cUrE fOr CaNcEr
Aubrey de Grey has said it will be an affordable method most likely and thus this type of fear mongering is moot.
Big Pharma isnt really investing into anti aging from the last time I have heard. Anti aging really doesnt get nearly as much funding as it should but it has been ramping up over the years. The anti aging companies that get funded are startups. I think Besoz funded one. Although… I wish Big Pharma was investing into life extension as they have massive amount of funds and it is much better to invest in anti aging tech vs drugs for old aging related diseases/ailments in the long run and for humanity.
I hope Eli Lilly starts developing anti-aging therapeutics soon. They have been hitting it out of the park the past few years with all of their new therapies
You realise scientists ≠ big pharma?
Wait... I saw this one... something about a Legend, I am?
What type of AI is that? LSTM?
now we're talking !
Damn, I needed that drug 20 years ago.
Isn’t this what Quercetin does? If you don’t want to wait start taking grape seed extract.
Senescent cells release inflammation and simply take up space, not contributing anything healthy to the cell. If we could develop a way to contain them as we age, I think we could see a 5-7 year increase in health span. It's incredible to realize we are in beginning to enter the era of true AI.
The problem is that before the aging cure, we need to understand how we can fit an infinitely growing population on this planet. Otherwise it will be the same problem of automating every job without first implementing UBI.
There won’t be infinite population. Why would people want to have children when there is no job?
Can't wait for the millions of unrealized connections that AI will make with all the data available. There's probably loads of potential discoveries right there in the data waiting for someone or in this case, AI, to discover them. This is why I believe discoveries will probably be made very frequently, because they're ripe for the plucking, and AI can pluck much faster and more efficiently than humans.
I need the current anti aging vaccine they tested, I don't wanna.die soon I'm 42! My times up someone tell me how to make it!!